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Gemcabene calcium

CAS No. 209789-08-2

Gemcabene calcium( PD-72953 | PD72953 )

Catalog No. M13313 CAS No. 209789-08-2

Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gemcabene calcium
  • Note
    Research use only, not for human use.
  • Brief Description
    Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.
  • Description
    Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP; down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM; lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.Hypercholesterolemia Phase 2 Clinical.
  • In Vitro
    Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2).
  • In Vivo
    ——
  • Synonyms
    PD-72953 | PD72953
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypercholesterolemia

Chemical Information

  • CAS Number
    209789-08-2
  • Formula Weight
    340.473
  • Molecular Formula
    C16H28CaO5
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 33.33 mg/mL 97.89 mM
  • SMILES
    CC(C)(CCCCOCCCCC(C)(C)C(=O)[O-])C(=O)[O-].[Ca+2]
  • Chemical Name
    6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid calcium salt

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bisgaier CL, et al. J Lipid Res. 1998 Jan;39(1):17-30. 2. Bays HE, et al. Am J Cardiol. 2003 Sep 1;92(5):538-43. 3. Yuan H, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7. 4. Srivastava RAK, et al. Front Pharmacol. 2018 May 11;9:471.
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