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Gemcabene calcium
CAS No. 209789-08-2
Gemcabene calcium( PD-72953 | PD72953 )
Catalog No. M13313 CAS No. 209789-08-2
Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGemcabene calcium
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NoteResearch use only, not for human use.
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Brief DescriptionGemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.
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DescriptionGemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP; down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM; lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.Hypercholesterolemia Phase 2 Clinical.
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In VitroGemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2).
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In Vivo——
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SynonymsPD-72953 | PD72953
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research AreaCardiovascular Disease
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IndicationHypercholesterolemia
Chemical Information
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CAS Number209789-08-2
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Formula Weight340.473
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Molecular FormulaC16H28CaO5
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Purity>98% (HPLC)
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SolubilityH2O : 33.33 mg/mL 97.89 mM
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SMILESCC(C)(CCCCOCCCCC(C)(C)C(=O)[O-])C(=O)[O-].[Ca+2]
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Chemical Name6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid calcium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bisgaier CL, et al. J Lipid Res. 1998 Jan;39(1):17-30.
2. Bays HE, et al. Am J Cardiol. 2003 Sep 1;92(5):538-43.
3. Yuan H, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7.
4. Srivastava RAK, et al. Front Pharmacol. 2018 May 11;9:471.
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